Abstract
Hybrid nanogels have been widely used as multifunctional drug delivery carriers and imaging probes for biomedical applications. Two triblock artificial polypeptides PC10A and PC10ARGD were biosynthesized to prepare hybrid nanogels. When the concentration of these polypeptides drops to less than 2% (w/w), they can form nanogels by self-assembly. The physical characteristics of nanogels, such as surface potential, size, and targeting domain are able to be tuned. Polypeptide–gold nanoparticles hybrid nanogels were in situ synthesized using PC10A(RGD) as templates and photoinitiator I-2959 under 365 nm UV light irradiation in one step. The results of the effect of gold ion concentration on synthesized gold nanoparticles in hybrid nanogels showed that the size and the concentration of gold nanoparticles in hybrid nanogel increased gradually with the increasing of gold ion concentration. The concentration of polypeptide has no obvious effect on the properties of gold nanoparticles in hybrid nanogels and only in...
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