Abstract
In recent years, microfluidic paper-based analytical devices (µPADs) have been developed because they are simple, inexpensive and power-free for low-cost chemical, biological and environmental detection. Moreover, paper is lightweight; easy to stack, store and transport; biodegradable; biocompatible; good for colorimetric tests; flammable for easy disposal of used paper-based diagnostic devices by incineration; and can be chemically modified. Different methods have been demonstrated to fabricate µPADs such as solid wax printing, craft cutting, photolithography, etc. In this study, one-step hot microembossing was proposed and demonstrated to fabricate µPADs. The processing parameters like embossing temperature, pressure and time were systematically investigated. It was found that, at 55 °C embossing temperature, the embossing pressure ranging from 10 to 14 MPa could be applied and the embossing time was only 5 s. This led to the overall processing time for fabrication of µPADs within 10 s. Glucose detection was conducted using the µPADs as fabricated, and a linear relationship was obtained between 5 and 50 mM.
Highlights
Since the 1980 s, microfluidics has emerged as an attractive research subject and been widely studied and explored for potential applications such as biomedical applications [1,2], drug screening [3,4], point of care applications [5,6,7], and environmental monitoring [8,9,10], for chemical and biological detection [11,12], etc
Wax printing is widely used to construct μPADs owing to its low cost, simplicity and relative rapidness and the total process duration can be reduced to 5–10 min [23,24]
Other techniques involved in utilization of the mold that are potentially more scalable, like stamping, calendaring and microembossing, have been developed to fabricate μPADs [26,27,28,29,30]
Summary
Since the 1980 s, microfluidics has emerged as an attractive research subject and been widely studied and explored for potential applications such as biomedical applications [1,2], drug screening [3,4], point of care applications [5,6,7], and environmental monitoring [8,9,10], for chemical and biological detection [11,12], etc. Other techniques involved in utilization of the mold that are potentially more scalable, like stamping, calendaring and microembossing, have been developed to fabricate μPADs [26,27,28,29,30] For this category of methods, construction of the microchannels is to use either a preheated, patterned metal stamp to press the paraffin-filled paper against the clean filter paper [26] or a heated stamp to press the photolithographically patterned parafilm against the filter paper [27]. The glucose detection was performed using the 00B5PADs as fabricated
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
