Abstract
Background and Objective: Imidazole scaffold is pervasive in pharmaceuticals and it possesses diverse type of biological activities, especially triarylimidazole derivatives are biologically prominent molecules which inspired the current investigation. The objective of the work is to synthesize 15 novel 2,4,5-triarylimidazole derivatives and evaluate their antimicrobial and antimycobacterial activity against selected bacterial and fungal strains.
 Methods: The title compounds 2,4,5-triaryl-imidazole were synthesized from the corresponding aryl aldehydes and keto-oximes through the cyclization to N-hydroxyimidazoles and reduced thermally to the different imidazole derivatives. Agar disc diffusion method is employed for the antimicrobial and antimycobacterial studies.
 Results: Fifteen novel 2,4,5-triarylimidazoles were synthesized in adequate yields and characterization of the molecules was done by detailed spectral analysis using advanced analytical support. Results disclosed that all the synthesized compounds were exhibiting antimicrobial properties. Compounds 3h, 3g, 3b, and 3m were stated to possess potent antimicrobial properties in the given bacterial and fungal strains.
 Conclusion: The current investigation results support the antimicrobial and antimycobacterial activity of the synthesized 2,4,5-triarylimidazole derivatives. Further, research is necessary to explore the mechanism involved in the antimicrobial activity.
Highlights
Imidazole is renowned for its diversified pharmacological activities and synthetic utilities
Fifteen novel 2,4,5-triarylimidazoles were synthesized in adequate yields and characterization of the molecules was done by detailed spectral analysis using advanced analytical support
Research is necessary to explore the mechanism involved in the antimicrobial activity
Summary
Imidazole is renowned for its diversified pharmacological activities and synthetic utilities. Imidazole is five-membered heterocyclic molecules cherished with two nitrogen atoms bridged through a carbon [1]. Since it can act as both base and weak acid, it acts as an efficient nucleophile to generate diversified molecules. Due to its ubiquitous applications as antimicrobial [7,8], antifungal [9], antiparasitic [10], antidepressant [11], antioxidant [12], and anticancer [13] and reported to possess anti-inflammatory [14], analgesic [15,16], and antidiabetic [17] properties, the current investigation was carried out to design and synthesize few imidazole-based molecules for the antimicrobial properties. The objective of the work is to synthesize 15 novel 2,4,5-triarylimidazole derivatives and evaluate their antimicrobial and antimycobacterial activity against selected bacterial and fungal strains
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