Abstract
A highly efficient one‐pot synthesis of 1,8‐dioxo‐octahydroxanthenes from dimedone and various aromatic aldehydes under reflux conditions in water, catalyzed by silica‐supported preyssler nano particles (SPNP) is reported. The products were formed in excellent yields and the acidic catalyst was completely heterogeneous and can be recycled for many times.
Highlights
Xanthene and their derivatives are an important family of organic compounds because they have wide range of biological and pharmaceutical properties such as antibacterial[1], antiviral[2], anti-inflammatory[3], anti-depressants and antimalarial agents[4]
We have reported in our earlier paper[33] about the synthesis and characterization of silica-supported Preyssler nano catalyst
We think that acid catalyst such as heteropoly acids might promote the reaction by accelerating the formation of enol from the 1,3-dicarbonyls such as dimedone, in the ratedetermining step (Scheme 2)
Summary
Xanthene and their derivatives are an important family of organic compounds because they have wide range of biological and pharmaceutical properties such as antibacterial[1], antiviral[2], anti-inflammatory[3], anti-depressants and antimalarial agents[4]. To avoid these limitations, the usage of a new and efficient catalyst with high catalytic activity, short reaction time, recyclable, suitable for green chemistry and easy to work-up for preparation of 1,8-dioxo-octahydroxanthenes would be highly desirable. We have reported in our earlier paper[33] about the synthesis and characterization of silica-supported Preyssler nano catalyst.
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