Abstract
Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe3O4 and γ-Fe2O3). The possibility of expanding the proposed technique for the synthesis of magnetic composite with embedded biologically active substance (BAS) of the 2-arylaminopyrimidine group was shown. The composition, morphology, structural features, and magnetic characteristics of the nanocomposites synthesized with and without BAS were studied. The introduction of BAS into the composite synthesis resulted in minor changes in the structural and physical properties. The specificity of the chemical bonds between BAS and the hydroxyapatite-magnetite core was revealed. The kinetics of the BAS release in a solution simulating the stomach environment was studied. The cytotoxicity of (HAP)FexOy and (HAP)FexOy + BAS composites was studied in vitro using the primary culture of human liver carcinoma cells HepG2. The synthesized magnetic composites with BAS have a high potential for use in the biomedical field, for example, as carriers for magnetically controlled drug delivery and materials for bone tissue engineering.
Highlights
Magnetic nanoparticles (NPs), both with a surface coating and within a host matrix, are widely used in bioapplications, including the separation and detection of biological substances, targeted drug delivery and labeling [1], diagnosis, and therapy [2,3,4,5]
We propose a modified coprecipitation hydrothermal method, which allows for the one-step production of a magnetic composite based on hydroxyappatite Ca10(PO4)6(OH)2 (HAP), including biological active substance (BAS) of the 2-arylaminopyrimidine series
Nanosized HAP used as a basis for the preparation of iron-containing composites (HAP) FexOy and (HAP)FexOy + BAS was synthesized from Ca(NO3) and KH2PO4 as the main material and NH3 as a precipitator under ultrasonic irradiation with an operating frequency of 30–40 kHz
Summary
Magnetic nanoparticles (NPs), both with a surface coating and within a host matrix, are widely used in bioapplications, including the separation and detection of biological substances, targeted drug delivery and labeling [1], diagnosis, and therapy (magnetic resonance imaging and magnetic hyperthermia) [2,3,4,5]. Enhancing HAP with magnetic NPs is promising for a number of procedures, including the treatment of microtrauma and other injuries, pro-osteogenic and pro-angiogenic activities [11], the printing of biologically compatible matrices for biomedical applications [12], carrying anticancer drugs [13], performing hyperthermia treatments [14], and resonance imaging. The combination of magnetic carriers and the drug protects the biological active substance (BAS) from chemical, enzymatic, and immune degradation on the way to a therapeutic target. Further progress requires the study of the chemical bond types of adsorbed BAS at the carrier surface [22,23] to understand the mechanism and duration of the payload release from the carrier, which is critically important for the effectiveness of therapy in general [24,25,26]
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