Abstract
A one-step synthetic method has been successfully applied to prepare IgG-capped aqueous colloids of noble metal (Au, Ag and Pt) nanoparticles (NPs), in which IgG is used as the solo stabilizing regent. The produced NPs were characterized by UV–vis spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. Both Au and Ag NPs prepared from this message show relatively narrow size distribution and form stable suspension in aqueous solution. The IgG-capped Au NPs exhibit much higher stability against high salt concentration than that prepared by conventional ligand-exchange method. The IgG molecules on the Au and Ag NPs can retain their bioactivity, which enables the NPs to bind with specific antigen. The IgG-capped Pt NPs were found to be less stable than the Au and Ag NPs, revealing different metal–protein interaction strength.
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