One‐step synthesis of 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid from isoflavones and arginine

Abstract

Abstract magnified image A simple and straightforward methodology toward the synthesis of novel 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid has been developed by one‐step reaction of isoflavones with arginine. A series of 14 new compounds was reported. All of them were characterized by FTIR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities making this methodology suitable for library synthesis in drug discovery. J. Heterocyclic Chem., (2010).