Abstract
In this paper, the reductive N-formylation, methylation and cyclization of amines with carbon dioxide (CO2) using sodium borohydride (NaBH4) at atmospheric pressure, via a one-pot two-step procedure, is presented. Formato borohydride (NaBHn(OCHO)4-n), in situ formed in the reaction of NaBH4 with CO2, as an efficient agent to promote the corresponding reaction, and the mechanism is proposed on the basis of experiments. This wide substrate scope and simple operational methodology also facilitates the effective synthesis of formamides, methylamines, benzimidazoles and other heterocyclic compounds avoiding high temperature and pressure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
