Abstract

A novel approach of forming thieno[2,3-b]quinoline derivatives (3a-h) was reported in the presence of copper oxide nano particles (CuO NPs). The reaction was conducted with 2-chloroquinoline-3-carbaldehyde as the precursor and its analogs (1a-h) which have undergone cyclo-condensation with thioglycolic acid (TGA, 2) and tetrahydrofuran (THF) solvent under reflux conditions (50 oC) for 2h. The synthesized CuO NPs were characterized by using PXRD and SEM-EDS instrumental techniques. The structural attributes of the organic compounds were confirmed with FTIR, 1H-NMR, 13C-NMR and Mass spectral techniques. The effectiveness of the CuO NPs in forming the compounds was evaluated by conducting the reaction with other metal oxides like ZnO, TiO2, NiO and it was observed that the CuO NPs were highly prominent in forming the desired compounds in higher yields and less time. Furthermore, the magnetic property of the CuO NPs was determined through hysteresis loop and the specific magnetization (Ms) was obtained at 19.79 emu/g. It indicates the prevailing magnetic property in the NPs, so that they can be easily separated from the reaction mixture. The anti-malarial activity of the compounds was evaluated using P. falciparum culture line with chloroquine (CQ) as the standard drug. In these studies, the thieno[2,3-b]quinoline derivatives with active functional groups have performed better than those with the deactivating group.

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