Abstract
Langerhans cell histiocytosis (LCH) is a rare and complex disease of unknown aetiology with an estimated reported incidence in adults ranging from 1–2 cases/million 1 Berber I. Erkurt M.A. Kuku L. et al. A rare disease in adult: Langerhans cell histiocytosis. World J Oncol. 2013; 4: 165-168 Google Scholar up to 8–9 cases/million. 2 Abla O. Egeler R. Weitzman S. Langerhans cell histiocytosis: current concepts and treatments. Cancer Treat Rev. 2010; 36: 354-359 Abstract Full Text Full Text PDF PubMed Scopus (185) Google Scholar Clinical presentation of LCH is very heterogeneous, ranging from a single-system involvement, generally benign, to a multisystem life-threatening disease. 2 Abla O. Egeler R. Weitzman S. Langerhans cell histiocytosis: current concepts and treatments. Cancer Treat Rev. 2010; 36: 354-359 Abstract Full Text Full Text PDF PubMed Scopus (185) Google Scholar
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