Abstract
1. 1. In both guinea-pig and rat heart, mitochondrial NADH-ubiquinone-reductase and soluble DT-diaphorase accounted for 49–50% and 48–50% of menadione metabolism, respectively. Microsomal NADPH-cytochrome P450-reductase was responsible for < 1% of menadione reduction. 2. 2. Menadione was a high-affinity substrate for all reductases ( K m values from 1 to 10 μM). 3. 3. Marked amounts of O − 2 (superoxide anion) were generated as a consequence of cardiac metabolism of menadione. 4. 4. Menadione-induced O − 2 generation was about 3-fold higher in guinea-pig than in rat heart. 5. 5. All results were compared with data obtained on guinea-pig and rat liver.
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