Abstract
Interleukin-15 has become a promising molecule in the context of eliciting an effective, antitumor immune response because it is able to stimulate cells of the innate and adaptive immune system. We generated an interleukin-15-expressing oncolytic influenza A virus for the treatment of an established murine tumor model. Our oncolytic influenza A virus produced large amounts of interleukin-15 and induced proliferation and activation of human Tcells invitro. Intraperitoneal administration increased the amount of mouse natural killer cells and effector memory Tcells, as well as Tcell reactivity invivo. Moreover, intratumoral injection induced a profound decrease in growth of established tumors in mice and increased the amount of tumor-infiltrating Tcells and natural killer cells. We established a stable, IL-15-producing oncolytic influenza A virus with promising immunostimulatory and antitumor attributes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
