Abstract
Since the introduction of molecular targeted agents for the treatment of metastatic renal cell cancer (mRCC), several treatment outcomes, including those from our facilities, have been reported. However, the outcome of these drugs, classified by the metastatic organs, is not well known. The present study reported the treatment results of molecular-targeted agents as classified by the metastatic organ at Osaka City University Graduate School of Medicine. A total of 180 consecutively treated patients who had received molecular targeted agents for metastatic renal cancer for 3 or more months were retrospectively analyzed. The overall survival was calculated and compared according to the Memorial Sloan-Kettering Cancer Center (MSKCC) criteria, the number of metastatic organs, and metastatic lesions. The median overall survival of patients with mRCC treated by molecular targeted agents was 34 months. A significant difference in survival rate between groups was found according to the MSKCC criteria. Patients with single metastatic organ lived significantly longer compared with those with metastases in multiple organs. Patients with pancreatic metastasis had a good response to molecular targeted drugs. Pancreatic metastasis, the number of metastatic organs, and MSKCC criteria were independent risk factors for overall survival. Treatment of mRCC by molecularly targeted agents did not show any difference by metastatic organs except for the pancreas, although its efficacy depends on the number of metastatic organs and the MSKCC classification.
Highlights
In 2017, six molecular targeted agents were approved for the treatment of metastatic renal cell carcinoma in Japan [1]
We retrospectively investigated the treatment outcome by metastatic lesion with molecular targeted drugs, and identified that pancreatic metastasis had better response compared to metastasis to other organs in the molecular targeted therapy era
It was reported that lymph node, bone, hepatic, and brain metastasis correlated with progression on univariate analysis, but not on multivariate analysis
Summary
In 2017, six molecular targeted agents were approved for the treatment of metastatic renal cell carcinoma (mRCC) in Japan [1]. We aimed to investigate the survival rate classified according to the metastatic lesion in the molecular targeted agents era for mRCC in Japanese patients
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