Abstract
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Highlights
On the rising incidence of early breast development: puberty as an adaptive escape from ectopic adiposity in mismatch girls
One of the proposed hypotheses is that an earlier/ faster maturation in girls is the phenotypic expression of an adaptive mechanism whereby girls attempt to escape from ectopic adiposity which, in turn, ensues from a mismatch between reduced prenatal weight gain and augmented postnatal weight gain [4]
In a recent issue of the European Journal of Endocrinology, Harbulot et al [11] reported how they performed the first test of the mismatch hypothesis, by analysing their single-centre cohort of girls with isolated variants of central precocious puberty (n = 319) in an unprecedented way: they distinguished three subgroups and calculated the Z-scores of birthweight-for-gestationalage and BMI-at-diagnosis-of-central-precocious-puberty in each subgroup
Summary
On the rising incidence of early breast development: puberty as an adaptive escape from ectopic adiposity in mismatch girls. In a recent issue of the European Journal of Endocrinology, Harbulot et al [11] reported how they performed the first test of the mismatch hypothesis, by analysing their single-centre cohort of girls with isolated variants of central precocious puberty (n = 319) in an unprecedented way: they distinguished three subgroups and calculated the Z-scores of birthweight-for-gestationalage and BMI-at-diagnosis-of-central-precocious-puberty in each subgroup Their findings (Fig. 1) endorse the mismatch concept since the three subgroups ('familial', 'sporadic', and 'adopted') tended to differ in birthweight (average centiles 50, 34, and 10, respectively) and in BMI-at-diagnosis (centiles 96, 90, and 76), so that the upward changes between birth and puberty amounted on average to 46, 56, and 66 centiles.
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