Abstract
While non-blood cell lineage has been studied for decades by developmental biologists, only recently has it been considered in disease. This is partly due to a lack of suitable reagents in experimental models, but it is also the result of a failure to understand the ability of cells to move or differentiate in pathological environments. This Editorial gives a quick overview of the Special Issue “Cell Fate Decisions in Development and Disease” and underscores the importance of understanding the mechanisms of cell fate determination and lineage.
Highlights
What are the origins of each cell in the body? This is a question that developmental biologists have been studying for decades using various experimental organisms including fruit flies, zebrafish, leeches, sea urchins, chick embryos and mice
The ability of inhaled nitric oxide (NO) to act as a vasodilator was discovered in the early nineties and its use to treat pulmonary arterial hypertension (PAH) became the standard of care
Another issue to consider is that of pathologies caused by the inability of progenitors to contribute to a tissue after injury
Summary
What are the origins of each cell in the body? This is a question that developmental biologists have been studying for decades using various experimental organisms including fruit flies, zebrafish, leeches, sea urchins, chick embryos and mice. Physicians have understood for many years that tissues and organs change in many ways after injury or illness. How do we define cells in pathologic human tissues? This is a powerful tool, but it is a flawed approach because while antibodies can identify the differentiated form of cells they do not tell us about their origin.
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