Abstract
Sequential staining of tissue sections with silver impregnation (Hellman and Hellerström's method), pseudoisocyanin and aldehyde fuchsin has resulted in the demonstration of two types of argyrophil cells in the pancreatic islets of the ratfish, Hydrolagus colliei. One type, accounting for approximately 50% of all islet cells, is identical to the x-cells described by Fujita in the pancreatic islets of a closely-related species, Chimaera monstrosa. The second category of argyrophil cells corresponds to the δ-cells described in Chimaera. The present morphological evidence suggests that the two types of argyrophil cells may be functionally independent and that they may be involved in hormone production.
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