Abstract
An analysis of nonspecific resistance in burn patients is conducted. The role of subpopulations of neutrophils and monocytes/ macrophages in severe burn injury is discussed. The significance of blood cells for the burn-induced immune dysfunction, susceptibility to sepsis and multiple organ failure is underscored. The involvement of secondary complications in the development of morbidity and mortality in patients with burn injury is shown. New approaches to identifying individuals with a risk of adverse outcome are considered.
Highlights
The annual frequency of severe burns, according to a European study [1], ranges from 0.2 to 2.9 cases per 10 thousand population
In burned patients, the subsequent systemic inflammatory response is accompanied by multiple organ dysfunction and immunosuppression phase, which increases the susceptibility to nosocomial infection [12]
A systemic inflammatory response syndrome masks the onset of burn sepsis, which delays the diagnosis of concomitant septicemia [13]
Summary
The annual frequency of severe burns, according to a European study [1], ranges from 0.2 to 2.9 cases per 10 thousand population. The main cause of deaths in hospitalized patients with severe burn injury is sepsis [8,9,10], which is associated with high (up to 85%) mortality [11]. In burned patients, the subsequent systemic inflammatory response is accompanied by multiple organ dysfunction and immunosuppression phase, which increases the susceptibility to nosocomial infection [12].
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