Abstract
Experiments were carried out to investigate the proposed involvement of the prostaglandin (PG) biosynthesis pathway in interferon (IFN) action. Several known inhibitors of fatty acid cyclooxygenase (indomethacin, ibuprofen, oxyphenylbutazone) were found to inhibit the antiviral action of IFN in mouse L929 and human FS-4 cells. However, the concentrations of these inhibitors required for this effect were much higher than those used to inhibit PG biosynthesis. Furthermore, we found that the inhibitors tested also blocked RNA and protein synthesis, and that the concentration dependence for these effects of the inhibitors and for the inhibition of IFN action were similar. This could account for the inhibitory effect of these compounds on IFN action without invoking an involvement of the cyclooxygenase pathway.
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