Abstract
The conversion of [3H]-androstenedione to testosterone regulated by the enzyme 17 beta-ketosteroid reductase and the conversion of [3H]-progesterone to 17 alpha-hydroxyprogesterone and onwards along the delta 4 metabolic pathway was studied in vitro in human testicular tissue from 32 males (2 fetuses, 25 adult, infertile men and 5 elderly men with prostatic carcinoma). Additionally, two prepubertal boys were studied with respect to the conversion of [3H]-androstenedione to testosterone in vitro, whereas another seven boys were studied with reference to the conversion of [3H]-progesterone in vitro. It appeared, that in all cases, the conversion of androstenedione to testosterone was larger than the conversion of progesterone to 17 alpha-hydroxyprogesterone by way of the 17 alpha-hydroxylase and onwards along the delta 4 metabolic pathway. It is thus concluded that the 17 beta ketosteroid reductase is not a rate-limiting enzyme along the delta 4 metabolic pathway. No case of deficient 17 beta-ketosteroid reductase was found among the 25 infertile patients studied.
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