Abstract
1.1. Treatment of mice and rats with the polyamine oxidase inhibitor N1,N4-bis-(2,3-butadienyl)- 1, 4-butanediamine (MDL 72527) causes a gradual accumulation of spennine in the circulation and a decrease of spennidine concentration.2.2. Spennine is mainly localized in the red blood cells.3.3. Co-administration of 2-(dinuoromethyl)omithine and MDL 72527 enhances considerably the rate and extent of spennine accumulation in the circulation.4.4. It is assumed that the increased rate of spennine accumulation by the two drugs is due to the enhancement of cell death, i.e. spennine accumulation is the result of its release into the circulation from dying cells, not due to physiological release.5.5. After discontinuation of polyamine oxidase inhibition spennine appears to be gradually transformed into spennidine by red blood cell polyamine oxidase, obviously without transformation into N1-acetylspennine.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
