Abstract
To evaluate the effects of fish oil supplementation on total triglyceride (TOT-TG), very-low-density lipoprotein TG (VLDL-TG), total cholesterol (TOT-CHOL), very-low-density lipoprotein cholesterol (VLDL-CHOL), low-density lipoprotein cholesterol (LDL-CHOL), and high-density lipoprotein cholesterol (HDL-CHOL) levels in adults with heart disease, 28 volunteers (all with documented vascular disease) were randomly assigned to either a fish oil treatment group or a soy oil group. Subjects consumed 7.8 g/d of either fish oil concentrate (containing 3.1 g ω3-PUFA) or a comparable quantity of soy oil for an 8-week period. The study was double-blind, and except for the addition of the supplements, the life styles of the subjects were not altered. Compliance was 97.5 ± 2.5%. Tasting blood was sampled at baseline, after treatment, and after 4 weeks of withdrawal. Samples were separated by ultracentrifugation and analyzed enzymatically. Only TOT-TG, VLDL-TG, and VLDL-CHOL showed a significant (P ± 0.05) group-by-time interaction by analysis of variance (ANOVA). Scheffe's post-hoc test revealed posttreatment values significantly different from baseline among the fish oil group, dropping 31.5%, 42.7%, and 28.6% for TOT-TG, VLDL-TG, and VLDL-CHOL, respectively. These values returned to baseline after the 4-week withdrawal period. The soy oil group had no meaningful or statistically significant lipid changes. In conclusion, fish oil had a significant effect on VLDL-CHOL, VLDL-TG, and TOT-TG in adults with heart disease.
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