Abstract
BackgroundApathy remains a disabling symptom in Parkinson's disease (PD) with limited therapeutic success. Processing of emotions and smell share neuroanatomical and evolutionary pathways. ObjectivesTo explore the association of apathy with smell dysfunction (SD) in early PD. MethodsWe analyzed patients with de-novo PD, with follow-up of at least 5 years from the Parkinson's Progression Markers Initiative. SD and apathy were defined using University of Pennsylvania Smell Identification Test and MDS-UPDRS part 1A. Odds ratios were calculated between apathy and olfaction groups. Kaplan-Meier survival analysis was grouped by presence/ absence of smell dysfunction. The Log Rank test was used to compare time to apathy. ResultsWe found no association between presence of apathy in patients with and without SD (OR 1.01 [0.49–2.08]). There was no significant difference between PD patients with and without SD in time to apathy (p = 0.72). ConclusionsSD does not portend greater risk of apathy in PD.
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