Abstract
Objectives: Free fatty acids (FFA) cause a rise in cytosolic free Ca2+ ([Ca2+]i) and stimulate insulin release from pancreatic β-cells. The mechanism by which FFA exert their effects on insulin secretion has long been thought to involve the uptake and metabolism of the FFA. The G-protein coupled receptor GPR40 or free fatty acid receptor 1 (FFAR1) can be activated by various FFA. We therefore investigated whether FFAR1 is involved in the generation of the FFA-induced Ca2+ signal and insulin secretion from pancreatic β-cells (INS-1 cells).
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