Abstract
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by skin lesions that begin as nodules and rapidly progress to necrotic ulcers. In some patients PG can exhibit extracutaneous organ involvement. Herein we present a 54-year-old male patient who presented with aphasia and headache. Computed tomography documented cerebellar abscess, which was subsequently drained and shown to be sterile. He was being followed with PG and this was accepted as cerebellar involvement. His case demonstrated a very extensive involvement of PG including the central nervous system, lungs, liver, and spleen. PG in this rare case of multiple organ system involvement had a very aggressive course, despite resection of an in-situ colonic adenocarcinoma.
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