Abstract

In the first half of the past century, it was thought that asthma was precipitated or prolonged by infection and that infection with several bacteria, including Streptococcus pneumoniae and Haemophilus influenzae, had a role in asthma.1 Some investigators had suggested that bacterial allergy or chronic focal infection could be a cause of asthma.2 More recently, population-based studies relating infections with Chlamydia pneumoniae and Mycoplasma pneumoniae to asthma severity encouraged a resurgent debate, but clinical trials involving various antibiotics failed to demonstrate sustained clinical benefit.1 To understand this debate we need to consider asthma and wheeze in children. The greatest incidence . . .

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