Abstract
PurposeTo investigate the normative data of ocular axial length and its associations in Chinese.MethodThe population-based Beijing Eye Study 2011 is a cross-sectional study performed in Greater Beijing. The study included 3468 individuals (1963 (56.6%) women) with a mean age of 64.6±9.8 years (range: 50–93 years). A detailed ophthalmic and medical examination was performed. Axial length was measured by optical low-coherence reflectometry.ResultsAxial length measurements were available for 3159 (91.1%) study participants. Mean axial length was 23.25±1.14 mm (range: 18.96–30.88 mm). In multivariate analysis, axial length was significantly associated with the systemic parameters of higher age (P<0.001), higher body height (P = 0.003), higher level of education (P<0.001) and urban region of habitation (P<0.001), and with the ocular parameters of thicker central cornea (P = 0.001), higher corneal curvature radius (P<0.001), deeper anterior chamber (P<0.001), thicker lens (P<0.001), more myopic refractive error (P<0.001), larger pupil diameter (P = 0.018), and higher best corrected visual acuity (P<0.001). It was additionally and negatively associated with the lens vault (P<0.001). In highly myopic eyes, axial length was significantly associated with lower level of education (P = 0.008), more myopic refractive error (P<0.001), and lower best corrected visual acuity (P = 0.034).ConclusionsMean ocular axial length in the older adult population of Greater Beijing (23.25±1.14 mm) was similar to the value measured in other urban populations and was higher than in a rural Central Indian population. The association between axial length and older age may potentially be associated with a survival artifact. The association between axial length and body height agrees with the general association between anthropomorphic measures and eye globe size. The association with the level of education and urban region of habitation confirms with previous studies. In contrast in highly myopic eyes, axial length was negatively associated with educational level and best corrected visual acuity.
Highlights
Variations in refractive error in older adults with an age of 50 years or more are mostly influenced by variations in axial length and in crystalline lens refractive power, followed by variations in corneal refractive power, and to minor degree by variations in lens thickness and anterior chamber depth [1]
Mean ocular axial length in the older adult population of Greater Beijing (23.2561.14 mm) was similar to the value measured in other urban populations and was higher than in a rural Central Indian population
Anterior segment optical coherence tomography (OCT) measurements were available for 1866 participants (1090 (58.4%) women) with a mean age of 64.069.6 years and a mean refractive error of was 20.1562.15 diopters
Summary
Variations in refractive error in older adults with an age of 50 years or more are mostly influenced by variations in axial length and in crystalline lens refractive power, followed by variations in corneal refractive power, and to minor degree by variations in lens thickness and anterior chamber depth [1]. Relatively few studies were focused on axial length in population-based studies. North China and South China, located at a distance of more than 4500 km from each other, show pronounced differences in climate, geography, living circumstances and nutrition, to mention only few parameters. It was the purpose of our study to obtain normative data of axial length and to examine associations between axial length and other ophthalmic parameters (such as corneal curvature) and systemic parameters (such as general anthropomorphic measurements and socioeconomic data) in a relatively large population from North China
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