Abstract
Answers 1. The changes in granulocyte nuclei morphology along with the presence of immature forms in peripheral blood (after the exclusion of myelodysplastic syndrome, leukemia, and infection) allowed us to diagnose the pseudo Pelger–Huet anomaly (PPHA). 2. A unilobed neutrophil in the patient’s peripheral blood. 3. It was decided to administer another dose of rituximab (Rtx), which resulted in the maintenance of CD20 lymphocyte depletion with subsequent remission of the nephrotic syndrome. This also allowed us to terminate corticosteroid therapy. Discussion
Highlights
CLINICAL QUIZOccurrence of neutrophil dysplasia in the course of severe nephrotic syndrome in a 12-year-old boy on immunosuppressive therapy: Questions
A 12-year-old boy has been treated since he was 9 months old due to severe, recurring, steroid-dependent nephrotic syndrome caused by focal segmental glomerulosclerosis (FSGS)
In 2013, at the age of 10 years, due to an increase in the frequency of relapses the patient was started on combination therapy with cyclosporine A (CsA) and mycophenolate mofetil (MMF)
Summary
Occurrence of neutrophil dysplasia in the course of severe nephrotic syndrome in a 12-year-old boy on immunosuppressive therapy: Questions. This article is published with open access at Springerlink.com
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