OC22.01: Embryonic growth discordance and early fetal loss in twins: the STORK multiple pregnancy cohort

Abstract

The aim of this study was to explore the association between discordance in embryonic growth and fetal loss at the time of the 11–14 week scan in twin pregnancies. Retrospective study of all twin pregnancies of known chorionicity from a large regional cohort over a ten-year period. Logistic regression, ROC curve and Kaplan Meier analyses were performed to evaluate the association between crown rump length (CRL) discordance at 7+0 to 9+6 weeks and spontaneous single fetal loss diagnosed at the 11–14 week scan. 1356 twin pregnancies were included in the study. There were 111 (8.2%) single fetal losses diagnosed at 11–14 weeks. At multivariate analysis, CRL discordance (OR: 1.20, 95% CI, 1.2-1.6) and CRL <5th centile of at least one twin (OR, 2.21; 95% CI 1.2-4.2), but not chorionicity or maternal age were independently associated with the loss of one fetus at the 11–14 week scan. The predictive accuracy of CRL discordance for single fetal loss was high (AUC=0.93; 95% CI=0.91-0.94). A significant association was found between the increase in the degree of embryonic discordance and the likelihood of early fetal loss (p<0.0001). Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.