Abstract
A study of correlation between preservation of the three-dimensional structure of chromosomes and their ability to undergo differential staining showed that chromosomes shaped like a convex half-cylinder give a regular pattern of longitudinal differentiation, but those shaped like concave half-cylinders do not. It was found that if the chromosomes are exposed for a brief period to the action of water during the staining procedure their outlines are changed and they become shaped like concave half-cylinders. Another method of obtaining chromosome preparations — ruling out possible exposure to water and increasing both the percentage of metaphase plates with differential staining of the chromosomes and also the quality of the staining — is thus suggested.
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