Abstract
Background Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular morbidity and mortality. Previous transthoracic echocardiographic (TTE) studies have demonstrated short term improvement in cardiovascular remodeling in OSA patients on continuous positive airway pressure (CPAP). However, due to the increased prevalence of obesity in OSA patients, the quality of TTE is often poor due to limited acoustic windows. Although cardiac MRI (CMR) is considered the gold standard for the noninvasive assessment of left ventricular (LV) dimensions, volumes and ejection fraction (EF) due to its higher spatial resolution, little is known about its utility in the delineation of LV remodeling in OSA patients on CPAP therapy over the long term.
Highlights
Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular morbidity and mortality
Cardiac MRI (CMR) is considered the gold standard for the noninvasive assessment of left ventricular (LV) dimensions, volumes and ejection fraction (EF) due to its higher spatial resolution, little is known about its utility in the delineation of LV remodeling in OSA patients on continuous positive airway pressure (CPAP) therapy over the long term
As early as 3 months, TTE revealed an improvement in left ventricular end-diastolic diameter (59 ± 5 mm to 52 ± 4 mm), right ventricular end-diastolic diameter (41 ± 3 mm to 36 ± 5 mm), and the degree of pulmonary hypertension (54 ± 6 mmHg to 42 ± 4 mmHg), which continued to improve over one year of follow-up
Summary
Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular morbidity and mortality. Previous transthoracic echocardiographic (TTE) studies have demonstrated short term improvement in cardiovascular remodeling in OSA patients on continuous positive airway pressure (CPAP). Due to the increased prevalence of obesity in OSA patients, the quality of TTE is often poor due to limited acoustic windows. Cardiac MRI (CMR) is considered the gold standard for the noninvasive assessment of left ventricular (LV) dimensions, volumes and ejection fraction (EF) due to its higher spatial resolution, little is known about its utility in the delineation of LV remodeling in OSA patients on CPAP therapy over the long term
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