Abstract
The healing process of superficial skin wounds treated with a blue-LED haemostatic device is studied. Four mechanical abrasions are produced on the back of 10 Sprague Dawley rats: two are treated with the blue-LED device, while the other two are left to naturally recover. Visual observations, non-linear microscopic imaging, as well as histology and immunofluorescence analyses are performed 8 days after the treatment, demonstrating no adverse reactions neither thermal damages in both abraded areas and surrounding tissue. A faster healing process and a better-recovered skin morphology are observed: the treated wounds show a reduced inflammatory response and a higher collagen content. Blue LED induced photothermal effect on superficial abrasions.
Highlights
LED-based devices are today changing photonics applications in various research fields
The microscopic imaging was performed on thin skin tissue cross-sections extracted from both treated www.biophotonics-journal.org wound (TW) and untreated wound (UW) areas from the animals used in the study
The combined Two Photon Fluorescence (TPF)-Second-Harmonic Generation (SHG) images are represented on the left for both UW (Figure 5A) and TW (Figure 5D)
Summary
LED-based devices are today changing photonics applications in various research fields This mature technology took strong advantage from the pioneering research conducted in the growth of Ga–N crystals during the 80’s by Akasaki, Amano and Nakamura that brought to the invention of the blue LED [1, 2]. When considering the absorption coefficient of skin chromophores in the UV-VIS-NIR spectrum (i.e. from 300 nm to 900 nm), haemoglobin exhibits narrow absorption peaks in the blue range (410 nm and 430 nm for oxygenated and non-oxygenated haemoglobin respectively), and its absorption coefficient is much higher than other skin chromophores [11,12,13] This particular property of haemoglobin can be used to ensure a local temperature increase that is able to induce hemostasis through a photo-thermo-coagulation process. Haemostasis is realized through a light-induced coagulation process, ensured by a spectrally selective and spatially localized photo-thermal effect [15]
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