Abstract
In this study, sunset glow fundus was evaluated in patients with Vogt–Koyanagi–Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 40 VKH eyes (20 patients) and 59 healthy eyes (59 age-matched controls). VKH eyes were divided into three groups according to color fundus images: sunset (17 eyes), potential sunset (13 eyes), and non-sunset (10 eyes). Choroidal melanin thickness (ChMeT) and the choroidal melanin thickness ratio (ChMeTratio) were calculated based on the degree of polarization uniformity from PS-OCT. ChMeT was significantly lower in sunset eyes than in non-sunset or control eyes (P = 0.003). The ChMeTratios of sunset or potential sunset eyes were significantly lower than those of non-sunset or control eyes (P = 0.04). Regional evaluation of ChMeT and the ChMeTratio showed that choroidal depigmentation predominantly occurred in the macula’s outer ring area (P = 0.002). The areas under receiver operating characteristic curves discriminating combined sunset (sunset and potential sunset) from non-sunset eyes were 0.983 and 0.997 for ChMeT and the ChMeTratio, respectively. Time course evaluation of 12 eyes from disease onset showed that ChMeT and the ChMeTratio significantly decreased over time. PS-OCT may be useful for objectively evaluating choroidal depigmentation in patients with VKH disease.
Highlights
In this study, sunset glow fundus was evaluated in patients with Vogt–Koyanagi–Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT)
We previously reported that PS-OCT was useful for objective evaluation of choroidal depigmentation in eyes with SGF12
Based on subjective evaluation of color fundus images of the eyes of patients with VKH disease, 10 eyes from six patients were classified as non-sunset, 13 eyes from nine patients were classified as potential sunset, and 17 eyes from 10 patients were classified as sunset
Summary
Sunset glow fundus was evaluated in patients with Vogt–Koyanagi–Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT). Objective approaches based on the ratio of color balance (sunset glow index)[8] and visibility of the choroidal vessels (choroidal vascular appearance index)[9] have been developed based on color fundus images These methods were unable to discriminate choroidal depigmentation from choroidal t hinning[10,11]. Volumetric measurement is required to evaluate heterogeneity of choroidal depigmentation in different locations Another limitation was that evaluation was performed at a single time point for each patient, with no time-course analysis[12]. Time-course analysis starting from disease onset is important to evaluate the development of SGF To overcome these limitations, we performed volumetric analysis using PS-OCT in this study to evaluate the distribution of choroidal depigmentation in patients with SGF. The development of SGF was investigated using time-course analysis
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