Abstract
OASIS-3 is the latest release in the Open Access Series of Imaging Studies (OASIS) that aimed at making neuroimaging datasets freely available to the scientific community. By compiling and freely distributing this multi-modal dataset, we hope to facilitate future discoveries in basic and clinical neuroscience. Previously released data for OASIS-Cross-sectional (Marcus et al, 2007) and OASIS-Longitudinal (Marcus et al, 2010) have been utilized for hypothesis driven data analyses, development of neuroanatomical atlases, and development of segmentation algorithms. OASIS-3 includes: demographics, raw neuroimaging, post-processed neuroimaging files, clinical assessments, neuropsychological testing, and biomarkers. OASIS-3 is a retrospective compilation of data for 1098 participants that were collected across several ongoing projects through the Knight ADRC over the course of 30years. Participants include 609 cognitively normal adults and 489 individuals at various stages of cognitive decline ranging in age from 42-95yrs. All participants were assigned a new random identifier and all dates were removed and normalized to reflect days from entry into study. All raw neuroimaging scans were converted to standardized NIFTI file format using dcm2niix and assigned BIDS (brain imaging data standard, Gorgolewski et al., 2016) standard naming conventions to improve analysis methods. The dataset contains over 2000 MR sessions which include T1w, T2w, FLAIR, ASL, SWI, time of flight, resting-state BOLD, and DTI sequences. Many of the MR sessions are accompanied by volumetric segmentation files as a result of Freesurfer processing. PET imaging from 3 different tracers, PIB, AV45, and FDG, totaling over 1500 raw imaging scans and the accompanying post-processed files from the Pet Unified Pipeline (PUP) are also available in OASIS-3. The OASIS-3 dataset hosted by central.xnat.org provides an easily accessible platform for use in neuroimaging, clinical, and cognitive research on normal aging and cognitive decline. OASIS-3 will provide the community with open access to a significant database of neuroimaging and processed imaging data in participants with normal aging and Alzheimer's Disease across a broad demographic, cognitive, and genetic spectrum. All data is available via www.oasis-brains.org.
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