Abstract
Background HIV infection leads to a progressive depletion of uninfected CD4 cells. We showed that NKp44L, a cellular ligand for an activating NK receptor is over-expressed during HIV infection and is correlated with both CD4 depletion and increase in viral load. NKp44L+CD4+ cells are highly sensitive to the NK lysis activity. However, HIV-infected cells are resistant to NK killing, suggesting that HIV-1 develop escape mechanisms to counteract NK cytotoxicity.
Highlights
HIV infection leads to a progressive depletion of uninfected CD4 cells
We show here that Nef protein induced the dysregulation of NKp44L surface expression on CD4 cells
This novel escape mechanism could play a key role in maintaining the HIV reservoir to ovoid recognition by NK cells
Summary
Address: 1Département de Virologie; Institut Pasteur, Paris, France and 2INSERM UMR945, Paris, France * Corresponding author from AIDS Vaccine 2009 Paris, France. 19–22 October 2009. Address: 1Département de Virologie; Institut Pasteur, Paris, France and 2INSERM UMR945, Paris, France * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):O23 doi:10.1186/1742-4690-6-S3-O23. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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