Abstract
The limited restorative capacity of mammalian tissues has been attributed to the loss of adequate cell replacement coupled with persistent inflammation with increasing age. Using mouse genetics we have investigated the role of growth factors and resident cells in the resolution of tissue injury. We have uncovered a complex interaction between local repair mechanisms and cells of the innate immune system, which participate in the removal of necrotic cells, secrete growth factors that limit inflammation and promote tissue replacement, and also act as tissue stem cells in the repair process. Our work supports the feasibility of improving mammali ets for clinical intervention and improving prospects for molecular and cellular combination therapies.an regenerative capacity by modulating key signaling pathways controlled by these cells, providing new targ
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