Abstract
Hematopoietic stem cell (HSC) transplantation is the only potentially curative, non-experimental therapy available to treat severe primary immunodeficiency disease. Precise regulatory mechanisms to support and maintain HSCs remain to be elucidated. Micro RNAs (miRNAs) have been shown in many systems to regulate stem cell function. This study focuses on miRNA-specific mechanisms that support and maintain HSCs.
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