Nutrition and Psoriasis: The Latest Evidence and How to Approach Nutrition in Clinical Practice

Celiac Disease: The Endocrine Connection

BACKGROUND AND OBJECTIVES:Celiac disease (CD) is an immune-mediated enteropathy, induced by gluten in genetically susceptible individuals. The objective of this study was to describe the clinical pattern of CD in children from the western region of Saudi Arabia.DESIGN AND SETTING:Retrospective, hospital-based.PATIENTS AND METHODS:This study included children with a biopsy-proven diagnosis of CD made between September 2002 and July 2007. Children were admitted to the endoscopy unit for a small-bowel biopsy if they had gastrointestinal symptoms suggestive of CD or if they were positive for a CD-antibody screen performed for the high-risk groups.RESULTS:Eighty children were identified with a diagnosis of CD. Their mean (SD) age was 9.6 (4.9) years (range, 0.5-18 years). There were 44 (55%) female patients. Forty-one (51%) patients were detected during screening of high-risk groups, while 39 (49%) patients had classical symptoms of malabsorption. The screening also detected asymptomatic patients. Of 65 patients tested, 11 (17%) had elevated liver function tests, which reverted to normal after introduction of a gluten-free diet (GFD) except in one case. Seventy-three (91%) patients were positive for anti-tissue transglutaminase antibodies, 18 (23%), for IgG anti-gliadin antibodies; and 46 (58%), for IgA anti-gliadin antibodies. Forty-one (56%) patients showed good adherence to GFD as assessed by dietary history and the decline in anti-tTG level.CONCLUSION:CD may present with classical symptoms or be identified through screening programs. Growth and laboratory abnormalities usually improve after introduction of a GFD. Adherence to a GFD remains a problem; therefore, thorough assessment and counseling at the time of diagnosis and ongoing care are crucial.

Follow-up of patients with celiac disease: Achieving compliance with treatment

What Is the Role of Serologic Testing in Celiac Disease? A Prospective, Biopsy-Confirmed Study With Economic Analysis

The diagnostic accuracy of serologic tests for celiac disease: A systematic review

Association of celiac disease and intestinal lymphomas and other cancers

Coeliac disease: changing diagnostic criteria?

Insufficient awareness of celiac disease in China: population-based screening is needed.

A negative fallout of COVID-19 lockdown in Italy: Life-threatening delay in the diagnosis of celiac disease

<h3>Introduction</h3> The majority of coeliacs have few obvious gastrointestinal (GI) symptoms despite the presence of the enteropathy, have atypical symptoms or have physiological derangements such as iron deficiency anaemia or osteoporosis. It is not clear whether these coeliacs have a reduced quality of life or whether quality of life changes following treatment with withdrawal of gluten from the diet. Johnson <i>et al.</i> (n = 14) observed silent coeliacs had no different life quality at diagnosis nor following 1 year of treatment in comparison to healthy controls1 though Nachman <i>et al.</i> (n = 8) observed silent coeliacs had significantly worse off quality of life in comparison to controls at diagnosis.2 Our aim was to describe the quality of life at diagnosis of coeliac disease in a large contemporary cohort and observe any change following treatment with a gluten-free diet (GFD). <h3>Methods</h3> 151 adults newly diagnosed with coeliac disease between 2007 and 2008 at Nottingham, Sheffield and Derby were studied. Quality of life was assessed with SF36 questionnaire. Paired t tests were used to examine changes in SF36 quality of life scores from diagnosis of coeliac disease and following 12 months treatment with GFD. Incident coeliacs were categorised as having a classic presentation (presenting with weight loss and diarrhoea, n = 22); presenting with GI symptoms (n = 85); or having occult disease (no GI symptoms or have physiological derangements such as anaemia in absence of GI symptoms, n = 44). <h3>Results</h3> Mean SF36 score at diagnosis of coeliac disease was highest in those presenting with occult disease (65.1 (SD 18.6)) and lowest in those with classic disease (48.7 (SD 19.3)). Following exposure to 12 months GFD, there was a statistically significant improvement in quality of life (table 1). The improvement in SF36 score with a GFD was similar regardless of their presenting symptoms at diagnosis. <h3>Conclusion</h3> Following diagnosis and treatment of coeliac disease with a GFD, we observed an improvement in quality of life that was similar regardless of the presenting symptoms and signs recorded at diagnosis and the baseline quality of life. Without a randomised controlled trial, we cannot be sure of the true magnitude of this effect over placebo.

Introduction The majority of coeliacs have few obvious gastrointestinal (GI) symptoms despite the presence of the enteropathy, have atypical symptoms or have physiological derangements such as iron deficiency anaemia or osteoporosis. It is not clear whether these coeliacs have a reduced quality of life or whether quality of life changes following treatment with withdrawal of gluten from the diet. Johnson et al. (n = 14) observed silent coeliacs had no different life quality at diagnosis nor following 1 year of treatment in comparison to healthy controls1 though Nachman et al. (n = 8) observed silent coeliacs had significantly worse off quality of life in comparison to controls at diagnosis.2 Our aim was to describe the quality of life at diagnosis of coeliac disease in a large contemporary cohort and observe any change following treatment with a gluten-free diet (GFD). Methods 151 adults newly diagnosed with coeliac disease between 2007 and 2008 at Nottingham, Sheffield and Derby were studied. Quality of life was assessed with SF36 questionnaire. Paired t tests were used to examine changes in SF36 quality of life scores from diagnosis of coeliac disease and following 12 months treatment with GFD. Incident coeliacs were categorised as having a classic presentation (presenting with weight loss and diarrhoea, n = 22); presenting with GI symptoms (n = 85); or having occult disease (no GI symptoms or have physiological derangements such as anaemia in absence of GI symptoms, n = 44). Results Mean SF36 score at diagnosis of coeliac disease was highest in those presenting with occult disease (65.1 (SD 18.6)) and lowest in those with classic disease (48.7 (SD 19.3)). Following exposure to 12 months GFD, there was a statistically significant improvement in quality of life (table 1). The improvement in SF36 score with a GFD was similar regardless of their presenting symptoms at diagnosis. Conclusion Following diagnosis and treatment of coeliac disease with a GFD, we observed an improvement in quality of life that was similar regardless of the presenting symptoms and signs recorded at diagnosis and the baseline quality of life. Without a randomised controlled trial, we cannot be sure of the true magnitude of this effect over placebo.

Gluten-Free Diets in Celiac Disease: Does Life Mean Life?

AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease—Changing Utility of Serology and Histologic Measures: Expert Review

Introduction and aim: Psoriasis is a chronic immune-mediated skin disease that is increasingly recognized as a systemic inflammatory condition linked to various comorbidities, including metabolic syndrome and cardiovascular disease. Lifestyle factors, particularly diet, are receiving growing attention for their potential to influence disease activity and treatment outcomes. This review explores current evidence on the role of nutrition in the clinical management of psoriasis, with a particular focus on dietary patterns such as the Mediterranean, Ketogenic, and Plant-Based diets, and their potential to improve both skin symptoms and overall systemic health. Methods and materials: This literature review draws upon sources accessed through the PubMed and Google Scholar databases, targeting publications from the last 15 years (2010–2025). The objective was to compile a wide range of scholarly works exploring the impact of dietary patterns on the management of psoriasis, with particular attention to Mediterranean, ketogenic, and plant-based diets. Search queries included terms such as “psoriasis,” “nutrition,” “Mediterranean diet,” “ketogenic diet,” and “plant-based diet.” The studies were selected based on their scientific credibility, relevance to the topic, and methodological integrity, ensuring that only high-quality and pertinent research was included in the final analysis. Results and conclusion: Diet may serve as an important adjunct to pharmacological treatment of psoriasis, influencing both the course of the disease and associated metabolic disorders. Anti-inflammatory dietary patterns, such as the Mediterranean, ketogenic, and plant-based diets, show promising therapeutic potential. Personalized nutritional recommendations and interdisciplinary care are essential for the effective and safe implementation of dietary interventions in clinical practice.

Objective: To identify the value of clinical data in diagnosis of celiac disease (CD) in children. Patients and methods: a prospective study was conducted in Mosul city during the period from 30th of October 2007 to 30th of April 2011. A total of 57 patients (39 males, 18 females) aged more than 6 months on gluten containing diet presented with symptoms suggestive of (CD) were evaluated clinically and serologically using IgA human recombinant tissue transglutaminase antibody. (IgA anti tTG2). Multiple duodenal biopsies were performed for every patient enrolled in this study. CD cases had been followed up 6 months after a gluten free diet (GFD) by weight measurement and the mentioned serological testing. Results: A total of 29 (50.9%) out of 57 symptomatic patients with mean age of 56.1 months, demonstrated positive biopsy results for celiac disease. Failure to thrive (FTT) was noticeable in 25 (86.2%) of studied patients with celiac disease followed by anemia, abdominal distension, offensive stool and chronic diarrhea in decreasing frequency. Catch up of weight was not achieved in 10 (43.5%) out of 23 CD patients with FTT whose (IgA anti tTG2) normalized after 6 months of GFD. Conclusions: The diagnosis of celiac disease on the basis of clinical features alone was incorrect in (49.1%) cases, indicating that diagnosis and lifelong GFD treatment is not justifiable relying on clinical data. Catch up of weight cannot be relied upon as an early marker of clinical improvement in patients with proven adherence to GFD. The result of this study emphasizes the importance of increasing awareness of the accurate tools in diagnosis of CD in children based on serological and biopsy evidences. Keywords: Celiac disease, clinical diagnosis, catch up of weight.