Numerical Modeling of Glucose Biosensor With pH-Based Electrochemical Field-Effect Transistor Device

Abstract

In this article, we present a new model for glucose detection using an electrochemical field-effect transistor (ElecFET) with the MATLAB software. ElecFET is a device in which the basic element is a pH-sensitive chemical field-effect transistor (pH-ChemFET) designed with an integrated platinum microelectrode around the sensitive gate dielectric capable to trigger electrochemical reactions. A number of parameters, such as polarization time ( ${T}_{\text {pol}}$ ) and polarization voltage ( ${V}_{p}$ ), have been investigated, as well as the enzymatic unit number per volume ( ${N}_{\text {enz}}$ ), the Michaelis constant ( ${K}_{M}$ ), and the glucose concentration ( ${C}_{{0}}$ ). Each of the aforementioned parameters influences the glucose sensor response. Experimental data compared with our numerical model showed a reasonable fit.