Abstract
In the present paper, we report a novel centrifugal microfluidic platform for emulsification and separation. Our design enables encapsulation and incubation of multiple types of cells by droplets, which can be generated at controlled high rotation speed modifying the transition between dripping-to-jetting regimes. The droplets can be separated from continuous phase using facile bifurcated junction design. A three dimensional (3D) model was established to investigate the formation and sedimentation of droplets using the centrifugal microfluidic platform by computational fluid dynamics (CFD). The simulation results were compared to the reported experiments in terms of droplet shape and size to validate the accuracy of the model. The influence of the grid resolution was investigated and quantified. The physics associated with droplet formation and sedimentation is governed by the Bond number and Rossby number, respectively. Our investigation provides insight into the design criteria that can be used to establish centrifugal microfluidic platforms tailored to potential applications, such as multiplexing diagnostic assays, due to the unique capabilities of the device in handling multiple types of cells and biosamples with high throughput. This work can inspire new development of cell encapsulation and separation applications by centrifugal microfluidic technology.
Highlights
Emulsions are produced in a mixture of two immiscible fluids, where the dispersed phase is suspended as droplets in the continuous phase
Cells can be enabled by such a novel system, as different types of cells can be accommodated in we present a novel centrifugal microfluidic featured withwhen
A novel centrifugal microfluidic device has been developed for droplet generation, and
Summary
Emulsions are produced in a mixture of two immiscible fluids, where the dispersed phase is suspended as droplets in the continuous phase. Emulsions are ubiquitous in our daily life and are widely used in the production of drugs, foods, cosmetics [1] and biochemical reactions [2,3] They are good candidates to synthesize micro-objects, such as particles and capsules for various chemical, biomedical, and industrial applications [4,5], including particle-based display technologies [6], photonic materials [7,8], field-responsive rheological fluids [9], tissue engineering scaffolds [10], therapeutics [11], high performance composite filler materials [12], consumer and personal care products [13], ultrasound contrast agents [14], drug-delivery vehicles [15], and food additives [16].
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