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Cardiac amyloidosis is an infiltrative cardiomyopathy responsible for a wide spectrum of clinical manifestations, including restrictive heart failure, arrhythmias, and conduction disturbances. High‑grade atrioventricular block is an uncommon but severe complication, frequently associated with poor prognosis. We report the case of a 58‑year‑old man followed for multiple myeloma complicated by renal amyloidosis, who presented with syncope revealing complete atrioventricular block related to cardiac amyloidosis, confirmed by cardiac magnetic resonance imaging. Through this case, we discuss the pathophysiological mechanisms linking amyloid infiltration to conduction system disease, as well as the diagnostic and therapeutic implications in light of current literature.