Abstract
A highly chemo- and stereoselective cleavage of acetals derived from (−)-(2R,4R)-2,4-pentanediol with organotitanium reagents has been demonstrated. The reaction proceeds under mild conditions in excellent yield and high chemoselectivity to give, after removal of auxiliary, the chiral alcohols of high enantiopurities. In addition, complexation of chiral acetals and TiCl 4 followed by treatment with n-butyllithium also results in formation of the corresponding n -butylated alcohols with high stereoselectivity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
