Abstract
Introduction: Perinatal asphyxia is a common problem with the incidence varying from 0.5 –2% of live births. According to World Health Organization, approximately 4 million babies die each year before they reach the age of one month. The number of NRBC/100 WBC is variable but is rarely greater than 10 in normal neonates. This simple test can be helpful in the rapid assessment of perinatal asphyxia. Material and Methods: This prospective case-control study and there were 82 newborns in Case and 82 newborns in Controls comprising of asphyxiated and nonasphyxiated neonates, respectively, over a period of 12 months. Results: Out of the 82 neonates in case group, fifty nine (59) neonates were found to have NRBC level ≥10/100WBC, out of which 58 (70.7%) were cases and 1(1.2%) was a control. NRBCs count of ≥10/100WBC were seen more in the newborn who had low 5 min Apgar score and in the newborn with severe HIE, these association were statistically significant (P value <0.001). The cut-off NRBC value of ≥10/100WBC also found to have a sensitivity of 70.30% with a specificity of 98.78%. NRBC has a positive predictive value of 98.31% with a negative predictive value of 77.14%. Significance and sensitive area for ROC curve was 0.875. The ROC curve was calculated with cut-off NRBC value of ≥10/100WBC.Conclusions: NRBC counts can be very useful to differentiate HIE newborns from non-HIE newborns which will help in appropriate management and better outcome of these newborns.J Nepal Paediatr Soc 2015;35(3):264-268
Highlights
Perinatal asphyxia is a common problem with the incidence varying from 0.5 –2% of live births.According to World Health Organization, approximately 4 million babies die each year before they reach the age of one month.The number of Nucleated Red Blood Cell (NRBC)/100 WBC is variable but is rarely greater than 10 in normal neonates.This simple test can be helpful in the rapid assessment of perinatal asphyxia
Perinatal asphyxia is a common problem with the incidence varying from 0.5 –2% of live births1, . 2,3,4 The highest annual neonatal deaths are in South Asia, where an es mated 51 deaths occur for every 1,000 live births[5] amongst which 21.0% of newborn mortality occurs due to birth asphyxia[5]
Newborn with perinatal asphyxia adjust to maintain adequate oxygen supply to central organs, aerobic metabolism is supplemented by anaerobic metabolism of glucose and glycogen to maintain cell and organ func on and this anaerobic metabolism produces lac c acid and releases hydrogen ions, which leads to fall in pH, rise in the base deficit of the extracellular fluid and glucose store will be reduced in this process
Summary
Perinatal asphyxia is a common problem with the incidence varying from 0.5 –2% of live births.According to World Health Organization, approximately 4 million babies die each year before they reach the age of one month.The number of NRBC/100 WBC is variable but is rarely greater than 10 in normal neonates.This simple test can be helpful in the rapid assessment of perinatal asphyxia. NRBCs count of ≥10/100WBC were seen more in the newborn who had low 5 min Apgar score and in the newborn with severe HIE, these association were statistically significant (P value
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