Abstract
Abstract The production of cloned animals following nuclear transfer using differentiated somatic cells grown in culture represents a remarkable aspect of developmental biology. In addition to the exciting opportunities for research there are many future practical applications in the fields of agriculture, conservation and medicine. Realizing these potentials will require a greater understanding of ‘nuclear reprogramming’, whereby the pattern of gene expression in somatic cells is reset to that at the zygotic state, enabling development to proceed.
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