Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs and are among the major causes of hypersensitivity reactions. NSAIDs can evoke different types of both immunological and non-immunologically mediated hypersensitivity reactions, and management of these reactions depends on type of hypersensitivity reaction. As NSAIDs are comprised of several drugs with different chemical structures which can inhibit both cyclooxygenases or selectively cyclooxygenase type 2 (COX-2), in most of the cases, it is possible to find a safe non-cross-reactive drug for a patient. However, in certain situations, especially when patients require anti-platelet treatment, patients can be desensitized to aspirin.

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