Abstract
A variety of case-control studies have been performed to assess the correlation between NQO1 C609T polymorphism and the risk of lung cancer, but an explicit consensus has not been reached. We conducted this updated meta-analysis to identify the function of NQO1 C609T polymorphism in lung cancer risk. All relevant literature was retrieved from the PubMed, EMBASE, CNKI, and WanFang databases before April 2017. A total of 37 studies (29 articles) with 8493 cases and 10,999 controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of relations. We found that the NQO1 C609T polymorphism did not correlate with the risk of lung cancer in the overall analysis. In addition, no statistical significance was observed in the analysis stratified based on ethnicity, control source, quality score, or smoking status. A significant association was found in the subgroup of small cell lung cancer risk. Despite some limitations, this meta-analysis indicates that the NQO1 C609T polymorphism may not be associated with lung cancer risk. However, more epidemiological studies of larger samples and more ethnicities are needed to confirm these results.
Highlights
Worldwide, lung cancer is one of the most common cancers and the leading cause of cancer-related mortality among men, and the fourth leading cause of cancer morbidity and the second leading cause of cancer mortality among women [1, 2]
5-year survival rate for lung cancer is less than 10%
No significant correlation between the NQO1 C609T polymorphism and lung cancer risk was observed in any of the genetic models
Summary
Lung cancer is one of the most common cancers and the leading cause of cancer-related mortality among men, and the fourth leading cause of cancer morbidity and the second leading cause of cancer mortality among women [1, 2]. In China, lung cancer ranks first among the causes of cancer-related death [3]. 5-year survival rate for lung cancer is less than 10%. A major reason for this outcome is that a large proportion of lung cancer patients are diagnosed at advanced stages. The definitive mechanism of lung cancer is not fully understood. Evidence suggests that lung cancer is a multifactorial disease caused by genetic and environmental interactions [4,5,6]
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