Abstract
The present work describes the novel synthesis of 3, 3'-((phenyl) (ethylamino) methyl)-4-hydroxy-2H-chromen-2-one derivatives catalyzed by biogenic ZnO nanoparticles. The synthesized heterocyclic compounds were characterized by fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) andmass spectrometric techniques. Absorption, distribution, metabolism and excretion properties and various toxicities (ADMET) studies and in silico molecular docking studies were carried out for the synthesized compounds. The synthesized compounds were screened for their efficacy towards the antioxidant activity and were subjected to corrosion inhibition study towards the mild steel in acidic medium by weight loss method. Additionally, the recyclability of the employed catalyst was studied.
Highlights
In the past decades, the aqueous environment has elicited much consideration in organic synthesis
The surface morphology and crystallinity were obtained by scanning electron microscopy (SEM), (CIIRC) and the elemental analysis of ZnO nanoparticles was conducted by energy dispersive analyzer using X-rays (EDX) (Thermo Scientific Noran 7)
A wide variety of catalysts, including L-proline, alum, tetrabutylammonium bromide, nano aluminum oxide (Al2O3), zeolites, bulk ZnO and biogenic ZnO NPs, were employed to study their efficacy for the synthesis of benzyl amino coumarins. 68% yield of product was obtained in 4 h by using bulk ZnO and the results are presented in Table 3 which illustrats that the presence of biogenic nano ZnO has given the products with 98% yield within 10–15 min
Summary
The aqueous environment has elicited much consideration in organic synthesis. Due to environmental issues, researchers have been functioning on the concept of diminished destructive effects to the environment to avoid the toxic effect of synthetic corrosion inhibitors [19,20,21] In this regard, several methods have been employed for the synthesis of different corrosion inhibitors for the MS. One of the methods of overcoming these drawbacks is using the metal oxide nanoparticles as catalysts due to their higher surface-to-volume ratio of nanoparticles (NPs) which is predominantly responsible for their catalytic properties. They actas paramount adsorbents for the multitude of organic compounds, amplifying the reactivity of the reacting molecules [22, 23].
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