Abstract

Methylbenzimidazole 1 reacted with 3-dicy- anomethylidine-1-ethyl-2-oxoindoline 2 in ethyl acetate to afford 1-amino-2-cyano-3,4-dihydro-1 0 -ethylspiro{benz- imidazo(1,2-a)pyridine-3,3 0 -indolin}-2 0 -one 6, which was used as a key intermediate in the synthesis of fused spiropolyheterocyclic derivatives of benzimidazopyrido- pyrimidine and/or benzimidazonaphthyridine nucleus incorporating an indoline moiety.

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