Abstract
Parkinson’s protein DJ-1/Park7, is a key regulator of redox signalling in neurons and muscles by regulating reactive oxygen species (ROS) production. Defects in DJ-1 are suggested to cause autosomal recessive early-onset Parkinson's disease. Further, deregulated DJ-1 signalling has been ascribed to other pathologies including diabetes (type II) and in obesity. How DJ-1/Park7 is involved in the maintenance of immune T cells especially suppressor regulatory T cells (Tregs) is not well defined. We explored this important question by using DJ-1 knock-out mice at cellular and molecular level. We found that DJ-1 is involved, both in vivo and in vitro, in the development of natural and induced Tregs. Differentiation of induced Tregs is regulated by mammalian target of rapamycin (mTOR)/Serum and glucocorticoid kinase 1 (Sgk1) and ROS/NF ƙ B pathway. Thus, our data highlights the importance of DJ-1 in the development of Tregs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
