Abstract
A novel protoparvovirus species, related genetically to human bufaviruses, was identified in dogs with respiratory signs. The canine bufavirus was distantly related to the well-known canine protoparvovirus, canine parvovirus type 2, sharing low amino acid identities in the nonstructural protein 1 (40.6%) and in the capsid protein 1 (33.4%). By screening collections of fecal, nasal, and oropharyngeal samples obtained from juvenile dogs (<1 year of age), canine bufavirus DNA appeared as a common component of canine virome. The virus was common in the stool samples of dogs with or without enteric disease and in the nasal and oropharyngeal swab samples of dogs with respiratory signs. However, the virus was not detected in nasal and oropharyngeal swab samples from animals without clinical signs.
Highlights
A novel protoparvovirus species, related genetically to human bufaviruses, was identified in dogs with respiratory signs
CBuV was more closely related to bufaviruses identified in primates (61.6%–63.2% nt similarity), pigs (59.6% nt), and bats (58% nt) [16,17,18,19,20] and more distantly related to canine parvovirus (CPV)-2 (45% nt)
The closest relatives to CBuV were protoparvoviruses identified in primates and other mammals [16,17,18,19], commonly termed as bufaviruses
Summary
A novel protoparvovirus species, related genetically to human bufaviruses, was identified in dogs with respiratory signs. The virus was common in the stool samples of dogs with or without enteric disease and in the nasal and oropharyngeal swab samples of dogs with respiratory signs. The virus was not detected in nasal and oropharyngeal swab samples from animals without clinical signs. Screening of enteric and respiratory samples from dogs with either gastroenteric or respiratory disease and from animals without clinical signs suggested a possible association between the novel virus and respiratory disease in young dogs. Parvoviruses have long been known in dogs, since the identification of canine minute virus, or canine parvovirus (CPV) type 1 (CPV-1; genus Bocaparvovirus), in 1967 from the fecal samples of healthy dogs [2].
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