Abstract
Currently, no bedside tools directly assess human placental function in vivo. We recently validated a hybrid optical/ultrasound instrument, which measures oxy-Hgb (HbO2) and O2 saturation (StO2) using frequency-domain near-infrared spectroscopy (FD-NIRS). Moreover, in a pilot study, we observed significant blunting of placental ΔHbO2 and ΔStO2 response to maternal hyperoxia in 3rd trimester pregnancies that later developed an adverse pregnancy outcome (APO) or had maternal vascular malperfusion (MVM) on placental examination.
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